Description and Composition Oral chews of 4 strengths and 2 pkt sizes are available: SENTINEL 2.3mg/46mg TAL, a chew containing 2.3 mg of milbemycin oxime and 46 mg of lufenuron. SENTINEL 5.75mg/115mg TAL, a chew containing 5.75 mg of milbemycin oxime and 115mg of lufenuron. SENTINEL 11.5mg/230mg TAL, a chew containing 11.5 mg of milbemycin oxime and 230 mg of lufenuron. SENTINEL 23mg/460mgTAL, a chew containing 23 mg of milbemycin oxime and 460 mg of lufenuron. Properties SENTINEL contains the active ingredients milbemycin oxime and lufenuron. Milbemycin oxime is a mixture of the macrolides milbemycin A3 oxime and milbemycin A4 oxime. Milbemycin oxime is active against nematodes and arthropods. Like other macrolides, milbemycin oxime interacts with the GABA receptors of the nervous system. Lufenuron is an insect growth regulator belonging to the group of benzoyl-phenyl-ureas (BPUs) and is classified as an insect development inhibitor (IDI). Like all BPU's, lufenuron acts as a chitin synthesis inhibitor. Treated immature fleas will not be able to molt to the next stage and females feeding on treated animals will produce eggs out of which no larvae will hatch. The interruption of the flea life cycle at various levels results in a long-term very effective flea control on the animal as well as in the environment. SENTINEL is well tolerated by dogs of all ages and breeds, including Collie breeds and breeding animals. Indications SENTINEL is an oral chew for the prevention and control of flea populations, the prevention of heartworm (Dirofilaria immitis) disease and the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum) and whipworms (Trichuris vulpis) in dogs. Dosage and Administration SENTINEL is given orally with a meal at the minimal dose of 0.5 mg milbemycin oxime and 10mg lufenuron per kg body weight according to the following table: Weight of dog Tablet 1 to 4 kg 1 Chew of SENTINEL 2.3mg /46mg > 4 to 11 kg 1 Chew of SENTINEL 5.75mg/115mg > 11 to 23 kg 1 Chew of SENTINEL 11.5mg/230mg > 23 to 45 kg 1 Chew of SENTINEL 23mg/460mg